A moving-boundary model of dissolution from binary drug-excipient granules incorporating microstructure

soluplus®; a novel excipient to improve dissolution rate of poorly water soluble drug, celecoxib

A moving boundary model of acrosomal elongation

A sperm penetrates an egg by extending a long, actin-filled tube known as the acrosomal process. This simple example of biomotility is one of the most dramatic. In Thyone, a 90 I~m process can extend in less than 10 s. Experiments have shown that actin monomers stored in the base of the sperm are transported to the growing tip of the acrosomai process where they add to the ends of the existing ...

Probabilistic methods for drug dissolution. Part 2. Modelling a soluble binary drug delivery system dissolving in vitro

The objective of this work is to use Direct Monte Carlo techniques in simulating drug delivery from compacts of complex composition, taking into consideration the special features of the dissolution in vitro environment. The paper focuses on simulating a binary system, consisting of poorly-soluble drug, dispersed in a matrix of highly-soluble acid excipient. At dissolution, the acid excipient d...

From Microstructures of Tablets and Granules to Their Dissolution Behaviour

Introduction Dissolution testing is now an established and standardised method for measuring the performance of drug products (1). It allows results for different batches of the same product,similar products from different suppliers, or tests from different labs to be compared. It is, therefore,a useful tool for quality control and for formulation development,so much so that the FDA has made it...

New allergy drug excipient allergy

Background Because of its rarity, drug excipients allergy is often unsuspected by the doctors. Some times the active drug is blamed and discontinued unnecessarily when the real culprit is drug excipients. This was suspected when patients reported exacerbation of urticaria with anti histaminic which are actually used for treating urticaria. After suspecting drug excipient as the cause of allergy.